New study investigates how jetlag can disrupt our metabolism
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New study investigates how jetlag can disrupt our metabolism


Have you ever felt sluggish and out of sorts after a long-haul flight or a late-night shift? A new study from the University of Surrey and the University of Aberdeen has found that disruptions to our body clock, such as those experienced during jetlag, impact our metabolism – but to a lesser extent than sleepiness and the primary clock in the brain.

Led by Professor Jonathan Johnston at the University of Surrey and Professor Alexandra Johnstone at the University of Aberdeen, the research involved a controlled experiment where participants experienced a 5-hour delay in their bedtime and mealtimes.

The study, published on iScience, highlights that the time shifts lead to:

  • Reduced energy spent processing meals.

  • Changes in blood sugar and fat levels.

  • Slower release of breakfast contents from the stomach.

These metabolic effects were temporary, however, and mostly recovered within 2-3 days of the 5-hour time delay. This was in marked contrast to the main clock in the brain, plus feelings of sleepiness and alertness, which had not recovered within 5 days of the 5-hour time delay.

Professor Jonathan Johnston, Professor of Chronobiology and Integrative Physiology at the University of Surrey, said:

“Our research underscores the importance of maintaining a consistent sleep schedule, particularly in our fast-paced world in which long trips and shift work are ever so common. Even a small time shift can impact many aspects of metabolism, but it now seems that metabolic consequences of jetlag recover far more quickly than impairment of sleep and alertness. Understanding the impact of circadian rhythms on our health can help us make informed choices about our lifestyle. By optimising our sleep and eating patterns, we can improve our overall wellbeing.”

Short-term changes in human metabolism following a 5-h delay of the light-dark and behavioral cycle

Alan Flanagan 1 2, Leonie C. Ruddick-Collins 3, Barbara Fielding 2, Benita Middleton 1, Johanna von Gerichten 2, Michael Short 4, Victoria Revell 5, Jeewaka Mendis 6, Claus-Dieter Mayer 7, Peter J. Morgan 3, Alexandra M. Johnstone 3, Jonathan D. Johnston 1 8

1 Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
2 Section of Molecular Medicine, Food and Macronutrients, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
3 The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, Scotland AB25 2ZD, UK
4 Department of Chemical and Process Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
5 Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, Guildford, Surrey GU2 7XP, UK
6 Surrey Clinical Trials Unit, Faculty of Health and Medical Sciences, Guildford, Surrey GU2 7XP, UK
7 Biomathematics and Statistics Scotland, University of Aberdeen, Foresterhill, Aberdeen, Scotland AB25 2ZD, UK

Received 21 July 2023, Revised 10 June 2024, Accepted 9 October 2024, Available online 11 October 2024, Version of Record 8 November 2024. Published: October 11, 2024

DOI: 10.1016/j.isci.2024.111161
Regions: Europe, United Kingdom
Keywords: Health, Well being

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