Alternative RNA Splicing in Cardiac Diseases
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Alternative RNA Splicing in Cardiac Diseases

07/02/2025 Compuscript Ltd
https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0060
Announcing a new article publication for Cardiovascular Innovations and Applications journal. Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or the selection of alternative splice sites modify transcript isoforms, which can consequently affect RNA molecules, including mRNA and non-coding RNAs, in terms of their localization, regulation, and overall function. In the cardiovascular system, AS of transcripts of sarcomere, ion channel, and cell signaling protein genes, as well as long non-coding RNAs, can contribute to the development of cardiovascular diseases. In addition, multiple hereditary heart-related diseases are caused by mutations associated with AS.
In this review, the authors discuss how AS regulates individual genes and global biological processes, thereby diversifying the expression patterns of target genes and playing critical roles in cardiovascular diseases. We also review the application of AS in the design of innovative therapeutic approaches.

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Mingze
Junli Gao, Yanan Zhang and Meiyu Hu et al. Alternative RNA Splicing in Cardiac Diseases. CVIA. 2025. Vol. 10(1). DOI: 10.15212/CVIA.2024.0060
Junli Gao, Yanan Zhang and Meiyu Hu et al. Alternative RNA Splicing in Cardiac Diseases. CVIA. 2025. Vol. 10(1). DOI: 10.15212/CVIA.2024.0060
07/02/2025 Compuscript Ltd
Regions: Europe, Ireland
Keywords: Health, Medical

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