Have you ever wondered if there is a way to heal bones without having to take bone from another part of the body? A new doctoral thesis from the University of Borås, Sweden, now presents exciting advancements in this area. It involves using bacteria to produce fibres that can help heal bones.

Sabrina Kopf, PhD in Polymer Technology, has investigated how a special type of bioplastic, polyhydroxyalkanoates (PHA), produced by bacteria, can be used.

"The idea is to use these fibres in textile structures that can support bone healing in cases of large bone defects. For bones to heal, bone cells need something to attach to. Bone cells recognise the substance calcium phosphate. Therefore, we have added this substance to the fibres," she explained.

The biggest challenge in the project was processing PHA into fibres with the equipment available in the laboratory. By melting the plastic and pressing it through a hole, similar to making spaghetti, she was able to produce fibres. These were then tested with bone cells to see if the cells could survive on the material.

"It turned out that it is possible to produce fibres with similar strength to bone. Additionally, we were able to produce simple knitted and woven textile structures from these fibres. The bone cells adhered to the material's surface and appeared healthy, which is a good sign," said Sabrina Kopf.

Great need for bone replacement materials

Bone is, after blood, the second most transplanted tissue in the world, indicating a significant need for bone replacement materials.

"Today, bone from the patient's own body is often used, meaning that bone is taken from, for example, the pelvis and transplanted to the damaged area in the body. This limits the amount of bone available. Additionally, the risk of complications at the donation site is high. Using synthetic materials like PHA fibres could be a solution to this problem," said Sabrina Kopf.

Environmentally friendly alternative

PHA fibres are also environmentally friendly. They can be produced from residuals and degrade in all types of environments without remaining as microplastics. This makes them a sustainable option for the future.

Advancements in biomedical research
"The results of my project are a small step forward in biomedical research and can inspire other researchers to explore the potential of textiles in medical applications," said Sabrina.

Research at the University of Borås focuses on sustainable development based on the global goals. Sabrina explained how this project connects to these goals:

"Being able to produce fibres from PHA benefits not only the healthcare sector, even though that was the approach of my thesis. The fibres can also be used in other textile applications and contribute in all aspects where textiles are involved in the UN's sustainable development goals, as PHA and its products are biodegradable and have no negative impact on the environment."

What is your next step as a researcher?

"I will start as a researcher in melt spinning at RISE in the fiber development department. So, I will work with the same technology I used in my thesis."

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Sabrina Kopf defended her thesis at the University of Borås, Sweden, on 23 April.
Read the thesis: Melt Spun Polyhydroxyalkanoate Filaments for Biomedical Applications
Main Supervisor: Professor Mikael Skrifvars
Assistant Supervisor: Docent Dan Åkesson and Maria Persson, Senior Lecturer
External reviewer: Professor Jānis Ločs, Riga Technical University
Read more about polymer technology research at the University of Borås
Read more about research in the field of Resource Recovery